(Young Scholar's Forum, May 18) Session at School of Food Science and Engineering
May 17,2017 08:25:02 readCount:109
Time: Thursday, May 18, 2017
Venue: Dongtang Hall, Building No.13, Wushan Campus
Opening Ceremony
Time: 9:00-9:05
Topic One: Structure and function of a ZIP zinc transporter, a central player in zinc metabolism
Time: 9:05-9:35
Speaker: Dr. Zhang Tuo(Michigan State University)
Zinc is the second most abundant essential microminerals (after iron) in humans, and 10% of proteins (~3000 proteins) encoded by human genome are predicted to be zinc binding proteins. According to the WHO, as high as 31% of people around the world are at risk of zinc deficiency. However, as a transition metal, excess zinc is toxic. Accordingly, a sophisticated control of systemic and cellular zinc homeostasis is vital for life. In human, two zinc transporter families play central roles in zinc homeostasis: Zrt/Irt-like protein (ZIP, SLC39) family and ZnT (SLC30) family are responsible for zinc influx and efflux across cell membrane, respectively. A total of fourteen ZIP proteins have been identified with diverse tissue/cellular distribution in human, which are broadly associated with a variety of human diseases. In this talk I will present the structural and functional results of a mammalian ZIP transporter extracellular domain (pZIP4-ECD) and a highly conserved transmembrane domain from bacterial (BbZIP). ZIP4-ECD reveals two structurally independent subdomains and an unprecedented dimer centred at the signature PAL motif. The BbZIP structure reveal two metals forms a binuclear metal center in the transport pathway.
Topic Two: Biosensors for enzyme detection and single molecule imaging of biomacromolecules
Time: 9:35-10:00
Speaker: Dr. Liu Rongrong(Nanyang Technological University,Singapore)
Biomolecule detection plays an important role in the fields of medical diagnosis, environmental monitoring and food safety. It has driven the increasing demand for developing simple, ultrasensitive and cost effective biosensors. With the rapid development of nanotechnology, nanomaterial-based biosensing platforms have emerged on the basis of their unique optical, electronic and catalytic properties. By coupling nanomaterial with biomolecular recognition events, the first gold nanoparticles based biosensor for sensing beta-lactamases and screening their inhibitors will be presented in this talk. Sequential sensing multiple enzymes and reversible manipulation of nanostructures with specific interactions will also be discussed. In this talk, Dr Liu will introduce the fluorescence imaging of biomacromolecuesby using single molecule technique. Imaging of single conjugated polymer nanodots (CPNs) and their superior optical features will be demonstrated.     

Announced by the School of Food Science and Engineering