(Lecture, Nov 16) Immune Cell-Mediated Cell and Drug Delivery Techniques
November 14,2017 16:11:00 readCount:36
Topic: Immune Cell-Mediated Cell and Drug Delivery Techniques
Speaker: Prof.Cheng Dong(The Pennsylvania State University)
Venue: Room 207, Building No.B6, University Town Campus
Time: Thursday, Nov 16, 2017, 14:30
 
[Abstract]
Immunotherapy has become a novel, but vital approach of treating some types of cancer in the last few decades. It takes advantage of a patient’s immune system to detect and destroy abnormal cancer cells. Brain cancer is a life-threatening disease due to its rapid development and the difficulty in its treatment. Despite modern treatment techniques (e.g. chemotherapy, radiation, and surgical removal), the median survival rate of glioma is less than 15 months after diagnosis. In adoptive cell therapy, one of cancer immunotherapy approaches, immune cells are removed from a patient/animal and either genetically modified or chemically treated, and can be re-introduced into the patient/animal in an attempt to improve the immune system’s anti-tumor response.
 
Here, we demonstrate different types immune cells’ ability to induce formation of brain endothelial gaps, transmigrate across the blood-brain barrier (BBB), and effectively deliver nanoparticle drug complexes to target primary or recurrent brain tumor. Our nanoparticles are made with biodegradable photoluminescent polymer (BPLP) and the intrinsic fluorescence of our polymeric nanoparticles enabled the facile tracking in vitro. Our work has shown potentials to improve the clinical management of patients with glioblastoma. We hope to identify new strategies to develop targeted immunotherapies for brain tumors using these techniques.
 
[Biography]
Dr. Dong is the department head and distinguished professor of Biomedical Engineering department at Pennsylvania State University. Dr. Dong obtained his B.S. from Jiao-Tong University in 1982. He obtained his M.S., M. Phil., and Ph. D. from Columbia University in 1984, 1986 and 1988, respectively. Dr. Dong’s work mainly focuses on biomechanics, cellular mechanics, cell signaling related to rumor and immuno-microenvironment, and immunotherapy and drug delivery. Dr. Dong published more than 100 SCI papers. Because of his outstanding works, he obtained many honors and awards, including Y.C. Fung Young Investigator Award, Junior Faculty Research award, Harold Lamport Young Investigator Award, Distinguish Professor, etc.
 

Announced by School of Biology and Biological Engineering